Airway oxidative stress in chronic cough

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Airway oxidative stress in chronic cough

BACKGROUND The mechanisms of chronic cough are unclear. Many reactive oxygen species affect airway sensory C-fibres which are capable to induce cough. Several chronic lung diseases are characterised by cough and oxidative stress. In asthma, an association between the cough severity and airway oxidative stress has been demonstrated. The present study was conducted to investigate whether airway o...

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Airway abnormalities at flexible bronchoscopy in patients with chronic cough.

The algorithms utilised in the diagnosis of chronic cough advocate sequential investigations and treatment trials for asthma-like syndromes, post-nasal drip and gastro-oesophageal reflux disease; however, the role of bronchoscopy is unclear. In the present authors' specialist clinic (North West Lung Centre Cough Clinic, Manchester, UK), flexible bronchoscopy is included in the diagnostic work-u...

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Airway inflammation in patients with chronic non-asthmatic cough.

INTRODUCTION Chronic non-asthmatic cough (CC) is a clinical challenge and underlying pathophysiological mechanisms remain still not completely understood. One of the most common comorbidities in CC is gastro-oesophageal reflux disease (GORD). Airway epithelium damage can contribute to airway inflammation in CC. AIMS We studied airway inflammation in patients with CC compared to healthy contro...

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ژورنال

عنوان ژورنال: Cough

سال: 2013

ISSN: 1745-9974

DOI: 10.1186/1745-9974-9-26